Get compounded semaglutide + B12 prescribed by a licensed U.S. provider via telehealth. No in-office visit. No brand-name markup. Shipped to your door starting at see pricingnth.
Start Your Semaglutide Protocol →Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist — a class of medication that mimics the body's natural satiety hormone. Originally developed to treat type 2 diabetes, semaglutide was later approved by the FDA for chronic weight management under the brand names Ozempic and Wegovy. Compounded semaglutide is a physician-prescribed medication dispensed by a licensed U.S. compounding pharmacy.
When injected subcutaneously once weekly, semaglutide binds to GLP-1 receptors in the brain's appetite-regulating centers, dramatically reducing hunger signals and slowing gastric emptying. This dual effect — less hunger and slower food transit — allows patients to eat significantly less without the psychological struggle of traditional calorie restriction.
At PeptidesRx, we prescribe compounded semaglutide with B12 (methylcobalamin). The B12 addition supports energy metabolism during caloric restriction and helps mitigate the fatigue some patients experience during dose titration. All compounded semaglutide is prepared by licensed U.S. compounding pharmacies under strict quality standards.
Activates GLP-1 receptors in the hypothalamus, signaling fullness and reducing food cravings — even before you start eating.
Food moves more slowly through the stomach, extending the feeling of fullness after meals and naturally reducing portion sizes.
Enhances insulin secretion in response to meals while suppressing glucagon, stabilizing blood glucose and reducing metabolic dysfunction.
By consistently reducing caloric intake over months, semaglutide drives sustained fat loss while preserving lean muscle — unlike crash diets.
Clinical trials demonstrate semaglutide produces 15–20% total body weight loss on average — results previously only achievable with surgery.
Semaglutide is appropriate for adults with a BMI ≥ 27 who have at least one weight-related health condition (such as high blood pressure, type 2 diabetes, or high cholesterol), or adults with a BMI ≥ 30 regardless of other conditions. It's also beneficial for individuals who have struggled with traditional diet and exercise approaches due to persistent hunger and cravings.
You may be an ideal candidate if you've tried multiple diets without lasting success, if your hunger feels uncontrollable, or if you carry excess weight that's affecting your energy, joints, cardiovascular health, or metabolic markers. Semaglutide works best as part of a comprehensive protocol that includes dietary improvements and regular physical activity.
Semaglutide is not recommended for individuals with a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, or those with a history of pancreatitis. A thorough health evaluation by our licensed providers will determine if semaglutide is right for you.
Semaglutide is titrated gradually to minimize side effects and allow your body to adapt. All protocols are set by your licensed provider.
| Phase | Dose | Frequency |
|---|---|---|
| Month 1 (Starter) | 0.25 mg | SubQ injection weekly |
| Months 2–3 | 0.5 mg | SubQ injection weekly |
| Months 4–5 | 0.75 mg | SubQ injection weekly |
| Month 6+ (Maintenance) | 1.0 mg | SubQ injection weekly |
* Dosage may be adjusted by your provider based on response and tolerability. All injections are subcutaneous (belly, thigh, or upper arm).
Most patients notice reduced hunger and increased satiety after meals. Some experience mild nausea — this is normal and typically passes within the first week.
Average 3–5 lbs of fat loss. Cravings for sugary and high-calorie foods diminish significantly. Energy begins to improve as blood sugar stabilizes.
Average 8–12 lbs of total weight loss. Dose is typically increased to 0.75mg. Patients report sustained appetite suppression, improved energy, and noticeable body composition changes.
Studies show 15–20% total body weight loss at 6–12 months. Improved metabolic markers, blood pressure, and quality of life. Maintenance dosing begins.
No hidden fees. No insurance required. Your provider consultation, prescription, and medication are all included.