Tirzepatide is a GLP-1 and GIP receptor agonist that supports weight management through dual receptor action. Get it prescribed online starting at $299/month — no insurance needed.
Start Your Tirzepatide Protocol →Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide is a dual GIP and GLP-1 receptor agonist studied for weight management and metabolic health. It represents the most advanced pharmacological weight loss therapy currently available.
Unlike semaglutide, which activates only GLP-1 receptors, tirzepatide simultaneously activates both GIP and GLP-1 receptors. This dual mechanism produces synergistic effects on appetite suppression, metabolic rate, and fat burning. Clinical trials (SURMOUNT) demonstrated average weight loss of 20–22% of total body weight — results that rival bariatric surgery outcomes.
At PeptidesRx, we prescribe compounded tirzepatide with glycine. Glycine is an amino acid that stabilizes the peptide formulation and supports metabolic health during the weight loss process. All compounded tirzepatide is prepared by licensed U.S. compounding pharmacies under rigorous quality controls, requiring a valid prescription from our licensed providers.
Activates both GIP and GLP-1 receptors simultaneously, creating synergistic appetite suppression and metabolic effects beyond either receptor alone.
Powerfully suppresses appetite signals in the brain's hypothalamus, reducing food intake by 30–40% in clinical studies.
GIP receptor activation improves insulin sensitivity in fat tissue and may increase basal metabolic rate — a unique advantage over GLP-1-only therapies.
Unlike crash diets, tirzepatide preferentially promotes fat loss while preserving lean muscle mass — critical for long-term metabolic health.
SURMOUNT trials showed tirzepatide producing an average of 20–22% body weight loss — the highest of any non-surgical weight loss treatment in history.
Tirzepatide is the premium choice for individuals who want the most effective weight loss therapy available or those who have tried semaglutide and want to advance to a more powerful protocol. It's particularly well-suited for adults with a BMI ≥ 27 with weight-related health conditions, or BMI ≥ 30 with or without comorbidities.
Ideal candidates include individuals with significant metabolic dysfunction (pre-diabetes, metabolic syndrome, high triglycerides), those with 50+ lbs to lose, or those who have "plateaued" on other weight loss medications. Tirzepatide's dual mechanism makes it especially effective for people with insulin resistance, where GLP-1-only therapies may be less effective.
As with semaglutide, tirzepatide is not recommended for individuals with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, or history of pancreatitis. Our licensed providers will conduct a full health evaluation to determine if tirzepatide is appropriate for you.
Tirzepatide is titrated gradually from 2.5mg up to 15mg maximum, with monthly dose increases based on tolerability and response.
| Phase | Dose | Frequency |
|---|---|---|
| Month 1 (Starter) | 2.5 mg | SubQ injection weekly |
| Months 2–3 | 5 mg | SubQ injection weekly |
| Month 4+ | 7.5–15 mg | SubQ injection weekly (titrate to max tolerated) |
* Maximum dose is 15mg weekly. Provider titrates based on response and tolerability. SubQ injections in belly, thigh, or upper arm.
Strong appetite suppression begins. Many patients report feeling full after very small meals. Mild nausea is common during week 1 and typically resolves quickly.
Average 4–7 lbs of weight loss. Cravings for high-calorie foods diminish. Blood sugar levels begin stabilizing. Energy may fluctuate as the body adapts.
Average 12–18 lbs of total weight loss. Dose increases to 7.5mg. Patients report significant body composition changes and improved metabolic markers.
20–22% total body weight loss achieved for many patients. Improved cardiovascular markers, energy, mobility, and quality of life. Maintenance protocol begins.
No hidden fees. No insurance required. Consultation, prescription, and medication all included.